Windows 2000

Windows 2000
Windows 2000 can be updated with an extended kernel and run Mypal and New Moon as well as Chrome 49. Windows 2000 works best on Pentium 4 era systems (for SSE2 support) or in a virtual machine.

NT 3.x
Windows 3.51, 3.5 and 3.1 are harder to set up but 86Box supports their era of hardware.

NT 4.0
Windows NT 4.0 is more easier to set up as virtualization software support them,VirtualBox and VMWare offers guest additions for them to use.